mRNA vaccines

posted in: Tech | 0

mRNA vaccines and therapeutics require less money to produce as compared to traditional medicines. They also offer higher effectiveness and enhanced immunogenicity. The vaccines are developed with the help of advanced technologies, having more efficacy against pathogens.

Infectious diseases such as HIV and chronic diseases like cancer, cardiovascular disorders, and diabetes will make the market for mRNA vaccines grow rapidly. The world sees surging demand for vaccines for influenza, Ebola, HIV, and other viral illnesses. Coupled with the inability of conventional methods to find vaccines on time will likewise spur market growth.

How mRNA vaccines compare to traditional vaccines

Inside the mRNA engine room

messenger RNA (mRNA) vaccine is a type of vaccine that uses a copy of a natural molecule called messenger RNA(mRNA) to produce an immune response. The vaccine transfects molecules of synthetic RNA into immunity cells. Once inside the immune cells, the vaccine’s RNA functions as mRNA, causing the cells to build the foreign protein. This would normally be produced by a pathogen (such as a virus) or by a cancer cell. These protein molecules stimulate an adaptive immune response which teaches the body how to identify and destroy the corresponding pathogen or cancer cells. The delivery of mRNA is achieved by a co-formulation of the molecule into lipid nanoparticles. They protect the RNA strands and helps their absorption into the cells.

Higher production speed and lower cost


The advantages of RNA vaccines over traditional protein vaccines are superior design and production speed. But also a lower cost of production, and the induction of both cellular as well as humoral immunity. The Pfizer–BioNTech COVID-19 vaccine requires ultracold storage before distribution. Other mRNA vaccines do not, such as the COVID-19 vaccines by ModernaCureVac and Walvax.


See how the mRNA vaccines work
Moderna personalized mRNA based cancer vaccines

Eczema-pill, are we there yet?

posted in: Fremhævet, Treatment | 0

Wouldn’t it be nice just to take a pill or some medicine every morning and heal your eczema?. Oh, yes!. But right now that is not an option.

Many companies are trying to get to this market first because they know how big it will be. There are hundreds of millions with eczema and other skin disorders worldwide. These patients are potential buyers of the new eczema medicine products that are coming to market now.

Eczema medicine is Big business

The pharmaceutical industry knows that many patients just want to heal their eczema with medicine or a pill. Because of that, the market for eczema-related drugs is expected to expand over the next decade. Of special interest is the new product Dupixent (biological medicine). The price is roughly $3,300 pr. month, but the initial dose is twice that amount.

Dupixent is produced in the ovary of Chinese hamsters. Prediction says that this drug alone will give the manufacturer a modern “money tree”. It grows forever since the patients are supposed to use it for the rest of their lives.

In one year, Dupixent earned € 679 million. It’s a little crazy that one type of eczema medicine can make so much money.

Eczema medicine sales trend
Eczema medicine sales trend

User reviews of DUPIXENT range from FANTASTIC to severe side effects. That includes inflammation of the cornea of the eye, extensive eczema flare-up, and of course “money-pain”.


Eczema expert Rob Stuart has basically the same approach to eczema healing as on this site. He has achieved total healing by reorganizing his diet and routines. It is affirming to know that my ideas and methods are in line with other eczema patients. People who have also healed themselves through lifestyle changes and skincare.

Click on the image to get to his channel and the more than 200 videos on eczema and natural eczema healing.

Rob Stuart is also concerned about these new potent eczema medicine products.


Have all options been tried?

My approach to eczema treatment is to have a strong focus on a healthy lifestyle and optimal skincare. Part of skincare is the daily bath and here I often see the greatest opportunities for improvement. Soaps in the bath are toxic to sensitive skin. Therefore replacing the soaps with salt or a regular washcloth is extremely important. The sensitive skin barrier is made up of skin cells and various lipids that need our protection. Soap, shampoo, and various soap-containing scrub products damage these lipids and thereby the skin.

The diet

Diet is important as it must contain all the vitamins, minerals, fiber, and nutrients that the body needs. In the diet, we also find foods and additives and sugar, which can create inflammation and thus cause eczema.

Overweight and obesity are major riskfactors for eczema. And eczema is a major risk factor for developing a weight problem. For that reason keeping the weight in check is of great importance.

A good indication of whether one is eating healthy is by looking at BMI and the body’s overall impression. If your BMI is in the lower part of the normal spectrum it indicates that not many unhealthy foods and sugars are consumed. If the body appears “trimmed”, it is a good indicator that the patient is on the right track diet-wise.

One should examine:

  • Is the diet healthy ?. It should consist of porridge, rye bread, healthy cold cuts such as fish, hummus, etc., fruits, and vegetables like carrots and cabbage.
  • Sugar intensifies inflammation in the body and needs to be eliminated from the diet.
  • Try to eat less fast food, ice cream, sweets, and other “empty calories” – They must be removed from the diet and replaced by healthy foods without preservatives and added sugar
  • Find allergens by using the “eczema-detective method” along with the dermatologist’s allergy tests

Why try natural healing?

The purpose of optimizing one’s lifestyle is to get as far in healing as possible in a natural way. The best result would be a total “cure”. Even if this is not possible a big improvement of the condition will also be good. Then you can settle for regular steroid creams (eg Locoid) and non-steroid creams (eg Elidel). It might be sufficient to keep eczema at bay while the skin is slowly rebuilding. One must never say “all or nothing”. Instead, think of it as a victory if you can achieve 75% improvement through an optimized lifestyle. You do not want to take the expensive and potent products that the pharmaceutical industry is currently rolling out. But With all the side effects are immediate and may not appear until many years from now.


The video below is about one of the first Danish patients on the DUPIXENT-treatment.

Bodyweight management

posted in: Diet, Fremhævet | 0

In this article, you will learn about what I think is the best fat-loss diet and the connection between overweight, obesity, and eczema.

As an eczema patient, it’s important to display some kind of bodyweight management. When a person develops eczema he is 8% more likely to become overweight or obese. But the opposite is also the case. A person that develops overweight or obesity is more prone to having skin problems like atopic dermatitis.

Effects of obesity on Skin

A 2017 study of American women found that skin barrier and moisturizing functions were significantly impaired by obesity, resulting in considerable dryness and roughness, compared with nonobese women.

Atopic eczema becomes a problem due to chronic inflammation in the whole body due to high caloric intake. That creates systemic inflammation combined with insulin resistance, demonstrated by altered levels of interleukin (IL)-6, leptin, adipokines, and insulin.

In another study published in the Journal of Allergy and Clinical Immunology, online March 16, 2011, the findings point to the same conclusions:

  • Small children who are obese may be more likely to develop severe eczema
  • Compared to children who weren’t obese, kids who became obese between the ages of 2 and 5 years old had more than three times the risk of developing the condition. If they were even younger when they became obese – babies or toddlers – their risk of the uncomfortable skin disease seemed to be even higher.
  • Children who are obese for a long time are more likely to get eczema. If you’re able to reverse the obesity with weight loss, children may be less likely to develop eczema, or eczema symptoms may improve.
  • Overall, the researchers found that obesity was nearly twice as common in children and adolescents with eczema. About nine of every 100 study participants with eczema were obese, compared to only five out of 100 without the skin disease.

The cost of overweight and obesity

The economic side of the matter is quite disturbing and the future outlook is not good. Healthcare costs are expected to rise dramatically in the coming years and place an already hard-pressed global healthcare system under even more pressure. For example, obesity is responsible for 70 percent of all treatment costs for diabetes, 23 percent of treatment costs for cardiovascular diseases, and 9 percent for cancers.

Congress to pass Legislation for Obesity – Trillions extra $ going to Medicare costs

BodyMassIndex

Health care providers use the Body Mass Index(BMI), which is a measure of your weight in relation to your height, to define overweight and obesity. People who have a BMI between 25 and 30 are considered overweight. Obesity is defined as having a BMI of 30 or greater. You can calculate your BMI to learn if you are overweight or obese. Being overweight or obese may increase the risk of health problems. Your health care provider can assess your individual risk due to your weight.

A good indication of whether one is eating healthy is by looking at BMI and the body’s overall impression. A BMI in the lower part of the normal spectrum may indicate that too many unhealthy foods and sugars are not consumed. If the body appears “trimmed”, it is a good indicator that you are on the right track with the current diet.

To keep the weight in check you have to exercise and eat healthily. In my free book Eczemahealingguide you can read more about a healthy diet that is optimal for fighting both eczema and weight problems. You will also learn some mental techniques to keep doing the right thing as a part of your future life.


The best fat-loss diet

My way of managing weight is in my honest opinion the best fat-loss diet. It is free, easy to do, and only demands a little self-discipline to get a lasting weight loss. If you keep to the routines and methods described you will be able to stay fit, lean, and healthy for life.

I am a small guy but even a small guy can put too much weight on sometimes. Of course, I can not relate to being overweight or obese, but I can share my methods to be in charge of my body weight.

Normally I put on some weight in the winter months. To get ready to hit the beach in the summer I start trimming down at Christmas-time by doing what I consider the best fat-loss diet and routines.

I have some rules that make it more like a routine than a struggle to lose weight. I guess it will work just as well if your start weight is somewhat higher. Then you will probably also see much quicker results at the beginning as the potential for losing weight is higher.

The routine

My rules for every day is like this:

  • Only coffee (with a little oat-milk) and carrots from I wake up and until lunch
  • At lunchtime, I have three pieces of rye bread with eg. cold cuts, salmon, mackerel, hummus, pâté.
  • At about 15 o’clock porridge made from oatmeal and müsli, no added sugar
  • For dinner, dishes with meat, fish or vegan steaks, falaffel, etc. as a protein source. Rice, bulgur, lentils, pasta, couscous ect. as a carbohydrate source. Rough green vegetables e.g. fried aubergines, broccoli, cabbage, scallions, carrots, etc. as a fiber / vegetable source.
  • Before bedtime again porridge made from oatmeal and müsli, no added sugar

I use a little oat milk in my coffee and peel the carrots before eating them.

The porridge is made like this:

  • 35 grammes of oatmeat + 35 grammes of müsli with no addad sugars
  • Add about 2 dl. cold water
  • Microwave for about 2.5 minutes at max wattage
  • Add 1 dl. of oat milk and 1 teaspoon of raw cocoa powder
  • Stir and let it sit for about two minutes

During the day there are no sugary soft drinks or similar things. Only juice, coffee, non-alcoholic beer, or pure water.

By keeping with this routine you do not have to think too much about what to eat and convincing yourself to eat healthy at every meal.

Of course, this diet is a little boring, but it is healthy and cheap. In fact, I find it to be the best fat-loss diet since it is so straightforward. It keeps you full and you always know what and when the next meal is there. By dividing the day into small manageable timeslots it is much easier to “stick-it-out” to the next meal.


No sugar

A major part the best fat-loss diet is to get rid of added sugar in your foods. Study also shows that high sugar levels can damage your brain and cause or worsen dementia.

The exclusion of sugar is no big problem and your body adapts quite rapidly. It is just like turning the volume of your stereo down and your ears will adjust. The craving for sugary foods hangs on for the first couple of days. At the beginning of the process, you are most motivated and eager to do the right thing. That helps to get through the first “tough” days and after that, it becomes much easier. Things like raisins, fruits, and daddles are small explosions of sugary taste and you will be surprised how easy it is to relinquish added sugar.

The video below is one of the best if you really want to learn about the mechanics behind the obesity epidemic. They are need-to-know knowledge if you are serious about your health. You that you will be surprised by the facts that are presented.

In this video you will learn about the food industry and how sugar makes you fat

Morning boost

To start the day with coffee and carrots are my prime choice. It is a power-boost of caffeine, fibers, vitamins, and antioxidants. Did you know that coffee has higher levels of antioxidants than blueberries?

Sometimes you will feel a little hungry at about 9 o’clock, but in a few hours, you will start your daily eating window. The foods I have listed all contain a high amount of protein, medium fats, and low natural sugars. On top, they have lots of fibers and healthy whole-grain carbohydrates to give energy and provide a feeling of satiety.


If you buy it – You eat it !

Another important part of the best fat-loss diet is to clean your house of any food that is not in sync with your goals and diet. This is again an important part of what I think is the best fat-loss diet.

To keep on the right path you must make a grocery list and stick to it. I have a saying: “If you buy it, You eat it”. Healthy foods need to be the only ones leaving the supermarket with you.

For the tempting times in the evening where the cravings come rushing in it is important to have a backup-plan in place. The plan is to have some healthy snacks ready in the cupboard. A bag of raisins, nuts, daddle or salty breadsticks can be the “emergency foods”. And when you crave a coke, then have some fruit juice. They may have the same calories, but now you got all the good vitamins instead of empty calories.

In the video below you will get even more knowledge about why we are in the midst of an obesity epidemic. This knowledge is good if you want to take back control of your lifestyle choices.

In this video you will learn about the food industry and how processed food makes you fat.
The effects of junk food in a person with food-addiction

Weigh yourself often to stay on track

It is crucial to jump on the scale every single day to maintain progressive fat loss. It has been confirmed by science that people who lost weight and kept it off have daily weigh-ins. If you get two “high” measurements you might feel your progress has stalled. That is normally not the case. You can just not see the trends if you only step onto the scale some days. Below you see the fluctuations of my daily measurements. They are canceled out when you zoom out to Year-view.

When I do my weight managing routine the result is a slow but steady lowering of my body weight. The rate of weight loss is just above one kilogram a month, which is a healthy rate to reduce your weight.


Exercise – Keep muscle and loose fat

In any fat-loss diet you have to get your body moving.

You have to find some kind of exercise that appeals to you. I lift weights one hour two times a week and aims at getting 10.000 steps every day. My apple watch keeps track of all the exercising data and the daily weigh-in is also going into Apple-health.

By exercising you maintain your muscle mass and by performing weight- or resistance training you build bigger muscle. When your muscle mass is greater your body burns more calories even when you are not training. It is just like a car with a big engine. It will have a higher fuel consumption when idle than a car with a small engine.

Going slowly in the weight loss process minimizes the risk of losing muscle mass. And doing progressive resistance training while in a caloric deficit, you tell your body to hold on to the muscle. Because of the high nutritional content on the diet, I experience muscle growth while slowly becoming leaner. That is really what you want!

Walking – Fat loss acceleration

Walking is the easiest way of spending more calories and keep muscle mass. The activity can be done everywhere and is free. The risk of injury is also extremely low compared to eg. running, playing football, or any other high-intensity sport. Combined with the fat-loss diet that I find to be the best, you can expect to see a gradual weight loss. But remember to be patient. Sometimes it takes just as long to fix it as it took to break it :-).

If I should recommend two videos about weight loss and walking it would be these two. They are my “go-to”-videos if I need some motivation myself or people are asking about weight loss advice.


Discipline

Committing to a healthy fat-loss diet and getting the exercise done can be hard. But if you do not eat healthily and burn more calories by training you will keep gaining weight. Some application of daily discipline is needed to stay on the right track. After the initial motivation has faded you have to rely on rules, routines, and self-discipline. It might be helpful to read my article about how I use and apply discipline to stay clear of my eczema condition and keep fit. Every day!


Before we dive deep into the subject of weight loss medicine, I would like to show you PLENITY. This is by my standards a smart product, that is not a drug, but a “Weight-loss device” according to the US. authorities FDA. By eating less you will lose fat and combined with a healthy diet, you are good to go.


Prescription Medications to Treat Overweight and Obesity

Photo by Moe Magners on Pexels.com

How do weight-loss medications work?

Prescription medications to treat overweight and obesity work in different ways. For example, some medications may help you feel less hungry or full sooner. Other medications may make it harder for your body to absorb fat from the foods you eat.

Who might benefit from weight-loss medications?

Weight-loss medications are meant to help people who may have health problems related to overweight or obesity. Before prescribing a weight-loss medication, your doctor also will consider

  • the likely benefits of weight loss
  • the medication’s possible side effects
  • your current health issues and other medications
  • your family’s medical history
  • cost

Health care professionals often use BMI to help decide who might benefit from weight-loss medications. Your doctor may prescribe a medication to treat your overweight or obesity if you are an adult with

Weight-loss medications aren’t for everyone with a high BMI. Some people who are overweight or obese may lose weight with a lifestyle program that helps them change their behaviors and improve their eating and physical activity habits. A lifestyle program may also address other factors that affect weight gain, such as eating triggers and not getting enough sleep.

Can children or teenagers take weight-loss medications?

The U.S. Food and Drug Administration External link (FDA) has approved most weight-loss medications only for adults. The prescription medication orlistat NIH external link(Xenical) is FDA-approved for children ages 12 and older.

Can medications replace physical activity and healthy eating habits as a way to lose weight?

Medications don’t replace physical activity or healthy eating habits as a way to lose weight and especially fat. Studies show that weight-loss medications work best when combined with a lifestyle program. Ask your doctor or other health care professional about lifestyle treatment programs for weight management that will work for you. Weight-loss medications don’t replace physical activity and a healthy fat-loss diet.

What are the benefits of using prescription medications to lose weight?

When combined with changes in behavior, including eating and physical activity habits, prescription medications may help some people lose weight. On average, people who take prescription medications as part of a lifestyle program lose between 3 and 9 percent more of their starting body weight than people in a lifestyle program who do not take medication. Research shows that some people taking prescription weight-loss medications lose 10 percent or more of their starting weight.

Weight loss of 5 to 10 percent of your starting body weight may help improve your health by lowering blood sugarblood pressure, and triglycerides. Losing weight also can improve some other health problems related to overweight and obesity, such as joint pain or sleep apnea. Most weight loss takes place within the first 6 months of starting the medication.

What are the concerns with using prescription medications to lose weight?

Experts are concerned that, in some cases, the side effects of prescription medications to treat overweight and obesity may outweigh the benefits. For this reason, you should never take a weight-loss medication only to improve the way you look. In the past, some weight-loss medications were linked to serious health problems. For example, the FDA recalled fenfluramine and dexfenfluramine (part of the “fen-phen” combination) in 1997 because of concerns related to heart valve problems.

Possible side effects vary by medication and how it acts on your body. Most side effects are mild and most often improve if you continue to take the medication. Rarely, serious side effects can occur.

Again this proves that doing your weight loss in a healthy way and natural way is the best option. Sticking to the fat-loss diet described above will the best choice you can make for yourself.

How long will I need to take weight-loss medication?

How long you will need to take weight-loss medication depends on whether the drug helps you lose and maintain weight and whether you have any side effects. If you have lost enough weight to improve your health and are not having serious side effects, your doctor may advise that you stay on the medication indefinitely. If you do not lose at least 5 percent of your starting weight after 12 weeks on the full dose of your medication, your doctor will probably advise you to stop taking it. He or she may change your treatment plan or consider using a different weight-loss medication. Your doctor also may have you try different lifestyle, physical activity, or eating programs; change your other medications that cause weight gain; or refer you to a bariatric surgeon to see if weight-loss surgery might be an option for you.

Because obesity is a chronic condition, you may need to continue changes to your eating and physical activity habits and other behaviors for years. Or even a lifetime to improve your health and maintain a healthy weight.

Will I regain some weight after I stop taking weight-loss medication?

You will probably regain some weight after you stop taking weight-loss medication. Developing and maintaining healthy eating habits and increasing physical activity may help you regain less weight or keep it off. Federal physical activity guidelines (PDF, 14.2 MB) recommends at least 150 minutes a week of moderate-intensity aerobic activity and at least 2 days a week of muscle-strengthening activities. You may need to do more than 300 minutes of moderate-intensity activity a week to reach or maintain your weight-loss goal.

What medications are available to treat overweight and obesity?

The FDA has approved five drugs—orlistat (Xenical, Alli), lorcaserin (Belviq), phentermine-topiramate (Qsymia), naltrexone-bupropion (Contrave), and liraglutide (Saxenda)—for long-term use. You can keep taking these drugs as long as you are benefiting from treatment and not having unpleasant side-effects.

Some weight-loss medications that curb appetite are approved by the FDA only for short-term use, or up to 12 weeks. Although some doctors prescribe them for longer periods of time, not many research studies have looked at how safe and effective they are for long-term use.

Pregnant women should never take weight-loss medications. Women who are planning to get pregnant also should avoid these medications, as some of them may harm a fetus.


Wegovy/Semaglutide – by Novo Nordisk

Approximately 650 million adults are estimated to live with obesity worldwide. So for that reason, the market for anti-obesity medicine is enormous. The medical firms that bring products to market that can reduce obesity will have a real “money tree”.

This drug is one of the most promising medicines for obesity. Novo Nordisk has taken one step forward in its ambition to move its Type 2 diabetes drug semaglutide into the giant and largely untapped obesity market. Semaglutide is an analogue of the human glucagon-like peptide-1 (GLP-1) hormone. It induces weight loss by reducing hunger, increasing feeling of fullness and thereby helping people eat less and reduce their calorie intake.

Novo Nordisk has in January 2021 unveiled plans to invest $80 million in expanding facilities at its production site in Denmark. The facility currently manufactures products for oral diabetes treatments and will be expanded to ensure capacity for future production of these products. The project is expected to be completed in 2022.
 
For Novo Nordisk it is an important step in building and ensuring future capacity for the production of Rybelsus (oral semaglutide). Their factory in Denmark is currently the primary site of production of oral semaglutide, and they say it is critical to invest timely in capacity expansion to meet future demands.

The money tree has been planted!

Wegovy costs $1.300 a month pr. patient!

FDA Approves New Drug Treatment for Chronic Weight Management, First Since 2014

This press statement is good news for Novo Nordisk.

Today (04. june 2021), the U.S. Food and Drug Administration approved Wegovy (semaglutide) injection (2.4 mg once weekly) for chronic weight management in adults with obesity or overweight with at least one weight-related condition (such as high blood pressure, type 2 diabetes, or high cholesterol), for use in addition to a reduced-calorie diet and increased physical activity. This under-the-skin injection is the first approved drug for chronic weight management in adults with general obesity or overweight since 2014. The drug is indicated for chronic weight management in patients with a body mass index (BMI) of 27 kg/m2 or greater who have at least one weight-related ailment or in patients with a BMI of 30 kg/m2 or greater. 

“Today’s approval offers adults with obesity or overweight a beneficial new treatment option to incorporate into a weight management program,” said John Sharretts, M.D., deputy director of the Division of Diabetes, Lipid Disorders, and Obesity in the FDA’s Center for Drug Evaluation and Research. “FDA remains committed to facilitating the development and approval of additional safe and effective therapies for adults with obesity or overweight.” 

Approximately 70% of American adults have obesity or overweight. Having obesity or overweight is a serious health issue associated with some leading causes of death, including heart disease, stroke and diabetes, and is linked to an increased risk of certain types of cancer. Losing 5% to 10% of body weight through diet and exercise has been associated with a reduced risk of cardiovascular disease in adult patients with obesity or overweight.

Wegovy works by mimicking a hormone called glucagon-like peptide-1 (GLP-1) that targets areas of the brain that regulate appetite and food intake. The medication dose must be increased gradually over 16 to 20 weeks to 2.4 mg once weekly to reduce gastrointestinal side effects.

The study

Wegovy’s safety and efficacy were studied in four 68-week trials. Three were randomized, double-blind, placebo-controlled trials (including 16 weeks of dose increases) and one was a double-blind, placebo-controlled, randomized withdrawal trial in which patients receiving Wegovy either continued with the treatment or switched to a placebo. More than 2,600 patients received Wegovy for up to 68 weeks in these four studies and more than 1,500 patients received placebo.

The largest placebo-controlled trial enrolled adults without diabetes. The average age at the start of the trial was 46 years and 74% of patients were female. The average body weight was 231 pounds (105 kg) and average BMI was 38 kg/m2. Individuals who received Wegovy lost an average of 12.4% of their initial body weight compared to individuals who received placebo. Another trial enrolled adults with type 2 diabetes. The average age was 55 years and 51% were female. The average body weight was 220 pounds (100 kg) and average BMI was 36 kg/m2. In this trial, individuals who received Wegovy lost 6.2% of their initial body weight compared to those who received placebo. 

Side-effects including Cancer

The most common side effects of Wegovy include nausea, diarrhea, vomiting, constipation, abdominal (stomach) pain, headache, fatigue, dyspepsia (indigestion), dizziness, abdominal distension, eructation (belching), hypoglycemia (low blood sugar) in patients with type 2 diabetes, flatulence (gas buildup), gastroenteritis (an intestinal infection) and gastroesophageal reflux disease (a type of digestive disorder).  

The prescribing information for Wegovy contains a boxed warning to inform healthcare professionals and patients about the potential risk of thyroid C-cell tumors. Wegovy should not be used in patients with a personal or family history of medullary thyroid carcinoma or in patients with a rare condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).  

Wegovy should not be used in patients with a history of severe allergic reactions to semaglutide or any of the other components of Wegovy. Patients should stop Wegovy immediately and seek medical help if a severe allergic reaction is suspected. Wegovy also contains warnings for inflammation of the pancreas (pancreatitis), gallbladder problems (including gallstones), low blood sugar, acute kidney injury, diabetic retinopathy (damage to the eye’s retina), increased heart rate and suicidal behavior or thinking. Patients should discuss with their healthcare professional if they have symptoms of pancreatitis or gallstones. If Wegovy is used with insulin or a substance that causes insulin secretion, patients should speak to their health care provider about potentially lowering the dose of insulin or the insulin-inducing drug to reduce the risk of low blood sugar. Healthcare providers should monitor patients with kidney disease, diabetic retinopathy and depression or suicidal behaviors or thoughts.

The FDA granted the approval to Novo Nordisk. Semaglutide 1 mg injection (Ozempic) was first approved as a treatment for type 2 diabetes in 2017.


KenDBerryMD is looking into this new weight-loss drug Wegovy

What other medications for fat loss may be available in the future?

Researchers are currently studying several new medications and combinations of medications in animals and people. Researchers are working to identify safer and more effective medications to help people who are overweight or obese lose weight and maintain a healthy weight for a long time.

Future drugs may use new strategies

  • combine drugs that affect appetite and those that affect addiction (or craving)
  • stimulate gut hormones that reduce appetite
  • shrink the blood vessels that feed fat cells in the body, thereby preventing them from growing
  • target genes that affect body weight
  • change bacteria in the gut to control weight

No Discipline – No Healing

After years of batteling eczema I have come to a conclusion that simply says: No Discipline – No Healing.

It is a hard reality and on my website, I speak truthfully about the cold facts about eczema healing. There is no quick fix and as a man You have to dig deep to find the natural power to win this battle.

During this winter I have not had a single eczema flareup. I have been using the knowledge and routines you can find in my free book, but knowledge is useless without the discipline to implement it.

Discipline is what keeps you on the right path and in time you will find it to be your best friend on the journey to eczema healing.

Mr. Eczema is always just behind you. He is ready to attack if you let your guard down. Eczema flareups are the pain he will inflict on your body and you instantly know that you have failed.

To stay on the right path and do what is right I often look to Jocko Willink. He is my Eczema Drill-instructor and his no-nonsense approach to daily discipline inspires me. His book Discipline Equals Freedom is a MUST-READ for every eczema-warrior. In the following, you will hear snippets from the book spoken by Jocko himself.

TRAILER for the book

Jocko’s message and voice is making Mr. Eczema duck for cover – He is really in trouble now!

The warpath

When I finally decided to confront Mr. Eczema head on I knew I had to go on the warpath. I felt there was no other way. Either I did it 100% or the path to permanent healing would be a long-drawn-out endeavor.

I grabbed my electric shaver, set it on 6 millimeters, and went into the shower. When I got out I had transformed. The guy I saw in the mirror was now looking like a real warrior and a rush of motivation to GET AFTER IT engulfed me.

Warpath by Jocko


Diet

It is important to stay clear of all the temptations that look so delicious, but you know will provoke a flareup. Even if the foods you are craving are not directly causing a flareup it might not be good for your overall health. As eczema-warriors we need to stay on the healthy path and always choose the healthier alternative.

Especially the exclusion of milk and eggs have been an issue that took a while to get on top of. But when I found out where these ingredients are found I just had to use my willpower to say no. That meant no more cakes, milkshakes, milk on the daily cereals and find the internal power to ask for alternatives when at a party or eating out. All these daily trials build and exercises your ability to handle your diet in a disciplined way and stay clear of ALL temptations and things that might contain the root for an eczema flareup. So far I have not had a flareup in more than a year, but I have not taken the chance on any food in that period either. You can do the same and trust me, its getting into a habit sooner than you might think. Discipline regarding diet is your best friend and make it able for you to go after other goals like getting lean and shredded for the beach next summer.

It is here you have to display the most will-power and have the overall goal in sight – to become free of eczema now and stay clear and healthy for the rest of your life.

As you know the road to eczema healing is not covered with cookies and doughnuts, instead it consists of healthy foods. It is a matter of imposing maximum will-power and execute on your knowledge about food each time you put food on the plate. You have learned all you need to know to make the right choices every time.

And when somebody suddenly comes by and offers free doughnuts…. I think Jocko has an opinion about that!

Sugar Coated Lies by Jocko


Stay disciplined every day

Even how hard you try sometimes you will make a wrong choice and an eczema flareup will come seemingly out of the blue. When that happens it is normal to feel overwhelmed and sorry for yourself. It is here you start doubting yourself and whether you have what it takes.

Instead of getting soft – Get angry.! Get more motivated than ever before and analyze the time up to the flareup like a forensic expert. Where did Mr. Eczema come from and what was his weapon?

I have had these seemingly out-of-the-blue eczema flareups several times.

Eczema caused by chemical fumes in paint
Should not have eaten that cake!. But now I know it can cause a flareup. Never again will Mr. Eczema be able to attack me with that weapon!.

Suddenly you feel the itching, stinging sensation of an eczema flareup about to explode in your face. But what can you do?. You will just have to take it head-on and focus on staying strong in the coming healing process.

Each time this has happened to me I have gotten a little closer to knowing my own eczema. By applying that knowledge and staying disciplined to do what is right, you can, like me, in time become 100% healed from eczema.

Application of Discipline by Jocko


Stay Focused

Every day is a new day to heal your eczema. By doing the right things and staying clear of all the temptations that can ruin your progress. Think of every day as an opportunity to become a tougher, more disciplined, and better version of yourself. Having this in mind you will eventually get there.

Challenging yourself is a great way to discipline your mind so it is strong when temptations come. Discipline also helps you to do the daily skincare routines and stay clear of soaps and perfumes.

I personally use the daily shower to train my mental will-power. By taking cold showers I do something that is not pleasant at the moment, but afterward, you feel like a superhero.

When the opportunity for a winter-dip in the fjord presents itself my mental will-power is really challenged. But there is no way I will pass on such a great opportunity to show Mr. Eczema who he is up against!

Ice-swimming build will-power
Will-power is forged in the icy waters of Denmark

So stay focused and stay disciplined. You can win this war, but some battles will be lost in the process. Accept that and just keep moving forward with a strong focus on the overall goal – To become eczema-free.

You can do it!

Focus by Jocko

For many people, a dairy-free diet helps them clear their eczema or at least makes it easier to reduce the severity of flareups.

Dairy-free diet helps eczema

posted in: Diet, Fremhævet | 0

For many people, a dairy-free diet helps them clear their eczema or at least reduce the severity of flareups. Since dairy products are a major trigger for eczema it is an important element in my diet to avoid foods that contain milk proteins.

Dairy products are things like cows milk, cream, cheese, yogurt, but also other foods can have ingredients that contain milk proteins. Fortunately, international regulations advice to have these allergens in the ingredient list on food products and the word milk must be included.

It was after a long period of bad eczema that I first started looking for other people’s experiences with diet change, as a way to treat atopic eczema.

I came across a post on the internet, where a guy describes how dietary changes have made his eczema disappear. Especially the exclusion of dairy and cow’s milk had made a great impact.

Motivated by the prospect of an eczema-free life, I instantly stopped drinking milk and also refrained from eating products that contained milk as an ingredient.

After a short while my eczema almost disappeared and to test if milk the cause, we did some quite unscientific tests at home with me as a guinea pig. The test was to refrain from all kinds of dairy products and then drink a small amount of milk after a couple of eczema-free days. The result was clear every time. After a minute or so of having milk eczema came again and always first as a tingling sensation in the skin which after a day became a visible eczema flare-up.

As an alternative to milk, I use oat milk from the supermarket. It is really good in coffee and muesli is now something I can eat again. In addition, oat milk has the advantage of very long shelf life and it stays fresh in the open state as long as it is in the refrigerator.

There are a growing number of brands so you have to test out which one you like the best.

A dairy-free diet seems to do the trick

Online you will find a lot of similar stories of eczema healing by excluding cows’ milk and dairy from your dairy. A good example of such a story is the one from Susan Marque in her post I Almost Died from Eczema: How a Nondairy Diet Saved Me.

It can be a combination of eczema and food allergies that make the road to healing more difficult. In this article from Healthline.com – How to Create an Eczema-Friendly Diet, this aspect is explained in an easy-to-understand way.

It reinforces my own experience in adjusting my diet to a dairy-free one and tells me that there is more to this subject than the established healthcare system and the dairy industry like to tell us.

Prostate cancer

If you are a man then your risk of having prostate cancer is increased by drinking milk. The higher the amount of fats in the milk, the more fatal the prostate cancer will be. High-fat content translates into aggressive cancer, whereas skimmed milk increases the chances of low-impact cancer. But both increase the overall risk of attracting this cancer that is widely spread in countries with a western diet high in sugars, processed foods, and dairy products.

You can read all about how a dairy-free diet has helped me to become eczema-free in my book Ezcema Healing Guide. But also just as important as why I just had to write a book, so that other eczema-sufferers can be inspired by my long journey to eczema-healing.


Goodbye to sore throat

When I drank cow’s milk and ate dairy products I had a sore throat every winter. It was a recurring phenomenon and if you have had a sore throat once, you know how painful it can be. Therefore, I was very relieved as after the first milk-free winter I had not had a sore throat.

It has been like that since my diet change abstaining from dairy and cows milk.

The Nasal rinser is my new best friend

posted in: Fremhævet, Skincare, The bath | 0

I am always looking for new ways to optimize my well-being and in that process, I stumbled upon nasal rinsing. It seems that a lot of people like this kind of cleansing, so I had to try it.

The nasal cavities act as a filter for the air you breathe in and are filled with cilia. Their job is to catch pollen and impurities before they reach the lungs.  This “air filter” is important for keeping the body healthy, but can also be a place where allergenic pollen and dust can accumulate over time.

In many Asian countries, it is just as normal to wash the nose in this way as it is to wash the rest of the body.

I’ve been using the nasal horn several times a week and have fallen in love with it. The first time you rinse your nose you that great feeling of the free airway, a bit like if you take a strong menthol candy. There is just so much more “throughput” that you become addicted to using your nasal rinser.

The way I use the nasal rinser is:

  • Fill the nasal rinser jug 3/4 with cold water.
  • Pour in salt with the included spoon. 
  • Pour to the brim with hot water from an electric kettle.  Thus you get approx. 37 degrees.
  • Stir with the back of the spoon until all the salt is dissolved.
  • Go into the shower and put the horn’s spout against one nostril.
  • Turn your head slowly and the water will run through your nasal cavities and out of the free nostril.
  • When approximately half of the water is used, you put your finger on the nostril where the nasal rinse’s spout is and blow water, etc.!  out of the free nostril.
  • After a few calm breaths, the procedure is the same on the other nostril.
  • Take a deep breath and enjoy the wonderful feeling of clean and free airways

Do not use lukewarm tap water, which could contain bacteria and other small insects that live in lukewarm water. That is most likely to occur in countries with primitive water distribution systems.

My preferred type of salt is sea salt. It does normally not contain an anti-caking agent, but there can be small impurities that you have to look out for.

To keep the nasal rinsing jug clean, I regularly give it a go in the microwave at 100% power with a little water in the bottom for about a minute. Be careful when you take it out, it is very hot.  Let it cool and it is fresh and ready to use again. 

EV-battery – Superhero of the future

posted in: Tech, Uncategorized | 0

Electronics have always been one of my great passions. Today I am lucky to work in the field of electronics and digital devices as a computer specialist. Technician by day, eczema healing guide at night. That is a great life :-).

On top of that I often see guys in my field of work that struggle with skin problems. If that is the case for you then the rest of this site is also for you.

I like to think about how the world will look like in 10-20-30 years. Especially with focus on how the technologies will keep transforming our societies. It is here I forsee the EV-battery as a fundemantal part of our infrastructure and transportationsystem. But also spilling into areas that we can’t imagine now.

Okay, on with the subject of EV’s and the lifecycle of their batteries and their many future applications in society.


First and foremost it is important that we take care of mother Earth as we evolve into a digitally dependant civilization. Our dependency on nature is not something we think about every day. But what good is it to get healthy and eczema-free if the planet is being destroyed by our lifestyle?

I think the electric revolution will spill into every part of our lives. Especially with the large numbers of batteries that are produced now and in the future. They will be of great value and have longer lifecycles than is the case now.

Their ability to store energy and act as a buffer will be used in many new applications. For that reason, I will tell about the my ideas of how we will see the area of batteries emerge in the comming decades. It is meant as an inspiration for people that are not that into tech and to open people’s eyes to the possibilities in batteries.

The main focus will be the repair and reuse of batteries. In a couple of years there will be extreme amounts of batteries that are still usable, but not for the application where they started their life. In the following we will look into the usecases of used, but still useable batteries.

This video explains the current situation about recycling of old batteries.


EV’s

As more and more EV’s come onto the roads it will be increasingly important to be able to fix and repair EV batteries.

Now electronics have been integrated into every part of our lives and our cars are rolling computers. The transition from ICE-vehicles to EV’s will be a cornerstone in the evolution of modern western countries. These vehicles are packed with electronics that all run on batteries.

The battery in an EV is the most expensive and environmentally problematic single part. It alone makes the production of a typical EV 74% more energy demanding than the production of a similar conventional car. On top of the energy demand during battery production, there is also a massive need for rare-earth minerals inside the battery itself.

Inspecting a module of an EV battery pack

To mitigate these dilemmas the need for efficient battery repair will be a necessary part of the future car market. By repairing instead of replacing an EV battery it is possible to save energy and materials that would otherwise go into the production of a brand new battery. It is also quite certain that the material- and production supply chain will be hard-pressed in the coming decade.

Research into the possibility of repairing a faulty battery pack shows it is possible to replace only a small part of the battery. Often it is only a few faulty cells that make the entire battery defective. These cells can be replaced by new cells that have the same characteristics as the original cell. Thereby reducing the cost of replacing the entire battery pack.

Another interesting aspect of battery repair is using old cells with sub-nominal capacity in low-demand applications. This could be power grid backup installations or as powerwall in your house. The areas of application of these used cells are vast.


Electric ships

Used cells have low capacity and their power-to-weight ratio is low. But in a ship, they could be used as ballast and at the same time act as a power source. Solar cells on the surfaces and superstructure of the ship would harvest the sun’s energy and store it in the ballast battery pack.

This ship is a fully electric ship and in the future, this kind of ship could be build using used cells from used EV battery packs.

Fully electric tanker
A new 60m-long tanker, named the e5, is the first of its kind to be powered solely by lithium-ion batteries.
This all-electric, battery-powered vessel will launch in Tokyo Bay next year (2022).
Credit: www.ship-technology.com/features/will-battery-powered-ships-take-over-the-industry/

By reusing old battery cells the EV battery repair industry will be able to lower their prices, since the used cells may be a resource instead of going to waste. This will profit both EV consumers and the business itself, but also the environment. The cells go through one more useful application, but recycling of the materials might be the last option.

Hand-eczema during the Corona-times

posted in: Fremhævet, Skincare | 0


During this corona-pandemic the focus on hand hygiene has given rise to an increasing issue in keeping the skin on our hands healthy.

It’s a simple imbalance between the amount of handwash and the body’s ability to keep the skin healthy. This may well be the root cause of the problems we are now seeing.

The excessive hand washing removes fats that hold the individual skin cells together. The result is that the skin barrier becoming leaky and allergens can enter the body.

When you get an eczema flare-up it is the immune system reaction to allergens that create redness and itching wounds on your skin. This phenomenon is called inflammation and is the body’s protective mechanism when allergens enter the body.

Skincare and treatment

To avoid a worsening of the eczema on your hands, it is essential to rebuild the skin barrier and at the same time treat inflammation.

After each hand-wash all soap should be rinsed well off and while hands are still moist, plenty of skin cream should be applied. You need a skin cream that is made for eczema skin and can replenish the skin with the compounds that are a natural part of our skin. It should be a cream that contains the same fats the skin now lacks and has lost due to the frequent washing. These are ceramides, cholesterol and fatty acids. They are binding agents between the individual skin cells and create a skin that does not allow allergens to enter, but keeps in the body’s moisture.

I have sensitive skin and have for more than ten years been investigating what works in my personal skincare. Countless products have been tested, but so far the most effective skincare cream is the one from CeraVe. It contains the right combination of ceramides, lipids and fatty acids naturally used by the body in production and maintenance of healthy skin.

By using CeraVe cream or creams with similar ingredients you can help your skin to cope with the hardships it is now beeing exposed to.

Use cream in the morning after your morning-bath, after each wash and before bed. Since the cream absorbs quickly into the skin you can use it frequently, especially during the first “reconstruction phase”.

To reduce inflammation, the eczema you may have should be treated with a topical steroid cream. I would choose Locoid, which you need a prescribtion for. It is a class 2 cream and is quite effective, but the risk of side effects is very small.

It is important not to be nervous about using topical steroids. It should be remembered that skin with eczema and inflammation itself is a dangerous condition that poses a risk of worse things in the future. Therefore, it is important to treat your eczema and follow up with effective skincare.


It is only when using class 3/4 creams for a very long time in the same area that you can experience side effects in the long run.

CeraVe – Moisturizing cream for eczema

posted in: Fremhævet, Skincare | 0

I find the CeraVe cream to be the best moisturizing cream for skin troubled by eczema. I found it some time ago after reading interesting articles about the benefits of ceramides. These fatty compounds should be good for people with a faulty skin barrier like eczema-patients since ceramides should fill the space between skin cells and act like mortar in a brick wall. Hmm… Sounds interesting…

On Amazon I saw thousands of positive reviews of the CeraVe-cream. After reading a lot of these reviews I had to try this cream and learn what this CERAMIDE was all about.

An extraordinarily high percentage of reviews are fire-stars.

I bought two jugs of CeraVe moisturizing cream 340 grams from lookfantastic.dk. It was reasonably priced compared to a lot of other moisturizing creams made for eczema. These often tend to be quite expensive and thereby being unattractive in the long run. 

CeraVe 340g cream
CeraVe seals info

Before we go my experiences with the cream we need to learn more about the main active compound in CeraVe creams, the ceramides.

Ceramides

Us with atopic dermatitis has dry skin and our skin barrier is compromised because we lack fats called lipids in the top layer of the skin. Ceramides are skin-identical compounds that are a normal part of our skin. In normal skin these fatty lipids represent approximately 50 percent of the top layer. They keep the skin resistant against allergens and inhibit water from escaping the body. Normal people can produce these lipids including ceramides to keep the skin barrier tight and sturdy. Eczema patients do not produce enough to fill the spaces between the skin cells and therefore the skin barrier becomes leaky.

By applying lipids and ceramides to the skin in the form of cream you can help the skin to hold cells together by adding these essential fats to the skin barrier.

This info-graphic shows how Ceramides works
This info-graphic shows how Ceramides works

As we age the skin becomes drier as the level of lipids in the skin diminishes. For that reason the importance of adding creams containing ceramides becomes more important as time goes on.

Ceramides can is made synthetically or from natural sources, but chemically they are the same. Together with other fatty lipids like glycerin, fatty acids, and cholesterol, ceramides can work wonders for eczema skin.

CeraVe cream is recommended by the National Eczema Association in the U.S

My verdict

This is the best cream I have ever used. The cream is silky smooth to apply and absorbs quickly into the skin. My skin is now soft, moist and feels more robust than ever before. The use of steroid creams have gone down and for now I am in a period where I do not use them anymore. If this holds up in the long run we will have to see, but for now I am very pleased.

When I shower and use mild soap and salt my skin is now still oily and feel not as exposed as before. It seems like this cream in a way fills up the skin with oils, so the barrier is intact even after the shower.

I have been using the cream daily for a week after the shower, at high noon and before bedtime. In that short amount of time I can literally say that my skin has changed.

All in all I am very impressed and my skin just loves this cream. Hopefully it will keep doing its job at keeping the steroid creams at bay. 

Read more about diet, skin care and much more in my book.

References:

Wikipedia/Ceramide

National Eczema Assosiation – Moisturizers for Skin Diseases: New Insights 

Make a stand now!

You have to make a stand and decide if you will commit to get rid of your eczema. My book will help you get on the road to permanent change. Once your eczema has cleared up and you get your energy back, you will not go back to your former life and diet.

It takes some self-discipline to avoid foods that you know will trigger your eczema. However, since you know the itching of red and inflamed skin from your own body, the risks of “taking a chance” are clear to you. That’s why you must firmly say “no!” to the food that you know or think may provoke an eczema flare-up.

The risk of “taking a chance” frequently leads to an eczema flareup that you have to treat with steroid creams for at least a week.

We all have a special mental tool we can use in a crisis situation. It is called the Warrior Mind and we all have it deep within ourselves. The Warrior Mind is a big asset in the healing process and will often provide you with the right course of action.

When weak-mind says CANDY, Warrior-mind says CARROT!!

Weak Mind is the voice in your head that’s always chattering and commenting. It likes instant pleasures no matter the consequences.

Warrior Mind is your intuition, your feeling that something is right. It will guide you to the best choices even if Weak Mind is complaining like a spoilt child.

Activate your Warrior Mind NOW!